منابع مشابه
Gate Control Theory Springs a Leak
Sun and colleagues (2017) find that individual Grp+ spinal interneurons can respond to and distinguish between stimuli that provoke itch or pain. The nociceptive response is limited by enkaphalin-expressing interneurons that are connected synaptically to the Grp+ neurons.
متن کاملGate Control Theory of Pain
The gate control theory of pain, put forward by Ronald Melzack (a Canadian psychologist) and Patrick David Wall (a British physician) in 1962, and again in 1965, is the idea that the perception of physical pain is not a direct result of activation of nociceptors, but instead is modulated by interaction between different neurons, both pain-transmitting and non-pain-transmitting. The theory asser...
متن کاملThe gate control theory of pain.
For example, you will probably be aware that there are times when, even though you have pain, you are only dimly aware of it. This may happen when you are really engrossed in doing something interesting or having to face a situation which demands all of your attention. A very good example of this is the stories you might have heard about wounded soldiers who, despite being seriously injured, wi...
متن کاملTesting the gate-control theory of pain in man.
According to the gate-control theory of pain, the electrical stimulation of large nerve fibres should stop the pain induced when only C fibres are active. This kind of pain was induced by pressure, repeated pinprick, cold and heat in the ischaemic limb. The peripheral nerves were electrically stimulated in the same way as is done by patients treating their chronic pain by electrical stimulation...
متن کاملTNF ROCKs the boat as the kidney endothelium springs a leak
Abnormal vascular permeability is a hallmark of sepsismediated injury to various organs. An intact endothelial barrier is critical to homeostasis and prevents leakage of abnormal quantities of fluid and protein, including proinflammatory cytokines and chemokines, into the extravascular space. Barrier disruption leads to distributive shock as well as organ dysfunction and edema (Lee and Slutsky ...
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ژورنال
عنوان ژورنال: Neuron
سال: 2017
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2017.02.016